Domain Therapeutics

Leveraging Years of Data on GPCRs for Transformative Drug Discovery
GPCRs, which play a role in most biological processes, remain one of the most vibrant fields for drug discovery. Years of data are increasingly being leveraged to overcome the complexity of GPCR biology and pharmacology and accelerate GPCR drug discovery. It is now possible to hope to rationally design drugs with optimal effects, thanks to a better understanding of the concept of functional selectivity. A growing volume of structural data also allows researchers to perform virtual screens with ever-increasing numbers of compounds and suggest new small molecule candidates in mere hours instead of months, allowing the exploration of a chemical space that seems infinite.